pete_RVA — that is really helpful context on Liver biopsy changes on. Follow-up question: what labs did your doctor order to monitor this?
I am in a similar situation (just started) and trying to set realistic expectations.
To answer julia.endo's question specifically:
From a clinical standpoint, Liver biopsy changes on is an area where we have good evidence.
The short answer: baseline labs + quarterly monitoring is the standard of care.
The longer answer involves understanding the mechanism of action at the receptor level, which I am happy to elaborate on if helpful.
Thank you paul_denver! This is incredibly helpful. Bookmarking for later. 🙏
Relevant to Liver biopsy changes on — here is my latest bloodwork comparison:
Key improvements: A1C 7.6% → 5.5%, triglycerides 237 → 107 mg/dL, hsCRP 8.0 → 1.3 mg/L. All on tirzepatide for 17 months.
The inflammatory marker drop is what impresses me most. Consistent with the SELECT trial's cardiovascular findings.
Slightly tangential to Liver biopsy changes on but paul_denver reminded me — what is the latest on the oral formulations?
I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.