stefan_berlin — that is really helpful context on GLP-1 and gluconeogenesis. Follow-up question: did you change anything about your diet at the same time?
I am in a similar situation (month 2) and trying to set realistic expectations.
Want to share my personal experience related to GLP-1 and gluconeogenesis since I think it might help others in a similar situation.
I started my GLP-1 journey in October 2024 at 285 lbs with prediabetes and hypertension. My endocrinologist prescribed semaglutide 0.25mg to start.
Now, 10 months later: I am down 65 lbs, my labs have normalized, and I am off 2 of my 3 medications. The GLP-1 and gluconeoge aspect specifically was something that made a big difference in my journey.
This community helped me every step of the way.
stefan_berlin — that is really helpful context on GLP-1 and gluconeogenesis. Follow-up question: did you experience any side effects during this phase?
I am in a similar situation (about to start) and trying to set realistic expectations.
Want to share my personal experience related to GLP-1 and gluconeogenesis since I think it might help others in a similar situation.
I started my GLP-1 journey in March 2025 at 257 lbs with metabolic syndrome. My telehealth provider prescribed semaglutide 0.25mg to start.
Now, 16 months later: I am down 72 lbs, my labs have normalized, and my sleep apnea has improved dramatically. The GLP-1 and gluconeoge aspect specifically was something that made a big difference in my journey.
This forum was my go-to resource throughout.
Just wanted to say — for anyone reading this GLP-1 and gluconeoge thread who is feeling discouraged: it gets better. The first few weeks are the hardest. Hang in there. 💪