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ForumsOral GLP-1 AgonistsSmall molecule vs peptide GLP-1 agonists — anyone have experience? Page 5

Small molecule vs peptide GLP-1 agonists — anyone have experience?

jason_paloalto Thu, Sep 18, 2025 at 10:31 PM 33 replies 1,842 viewsPage 5 of 7
Dr.ObesityLA
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Sep 19, 2025 at 5:36 AM#21

Reading this thread on Small molecule vs peptide hits close to home. Night shift nurse — I started at 291 lbs and felt like I would tried everything.

7 months on tirz and I am a different person. Not just the 66 lbs lost — my energy, my mood, my relationship with food. All transformed.

If you are on the fence about Small molecule vs — take the leap. It was the best health decision I have ever made. ❤️

2 14zoe_NC, Dr.ObesityLA
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Admin
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Sep 19, 2025 at 5:53 AM#22

Moderator note: Reminder: nothing posted here constitutes medical advice. Consult your healthcare provider.

Tagging this for the weekly digest. 👍

Last edited: Sep 19, 2025 at 9:53 AM
27 23SleepDoc_PDX, RegAffairsDC, BiostatsBrad and 24 others
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Dr.RaviCardio
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Sep 19, 2025 at 6:10 AM#23

Relevant to Small molecule vs peptide — here is my latest bloodwork comparison:

Key improvements: A1C 8.0% → 5.3%, triglycerides 243 → 113 mg/dL, hsCRP 6.0 → 1.3 mg/L. All on tirzepatide for 11 months.

The inflammatory marker drop is what impresses me most. Consistent with the SELECT trial's cardiovascular findings.

14 21mark_tokyo, hans_munich, jason_sac26 and 11 others
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nick_SD_fit
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Sep 19, 2025 at 6:27 AM#24

Thank you Dr.LeslieOBGYN! This is incredibly helpful. Bookmarking for later. 🙏

14 22PharmacoVig_BOS, SurmountFan_IN, PeptideChemSF and 11 others
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Dr.Martinez
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Sep 19, 2025 at 6:44 AM#25

+1 to GenomicsKate. Especially the point about "Small molecule vs peptide is exactly wha..." — I have seen the same in my own experience with Small molecule vs peptide.

27 8adam_van, Dr.SurgeonPGH, rachel_ABQ and 24 others
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