Hot take incoming: glp-1 and addiction pathways looking for.
I know this is controversial here but I think the conventional wisdom on this topic might be overly simplistic. Before you grab your pitchforks, hear me out.
My argument is based on conversations with my provider who has a different perspective.
Change my mind. Seriously — I want to be wrong about this if I am.
DanielChem_CHI's experience with GLP-1 and addiction resonates deeply with mine. I went through almost the identical process — starting dose, titration timeline, side effects, everything.
The main difference: I titrated faster. But the overall trajectory has been remarkably similar. Down 64 lbs in 9 months.
One thing I would add that DanielChem_CHI did not mention: the relationship with food fundamentally changed.
Thanks for sharing this, DanielChem_CHI. A few questions about your GLP-1 and addiction experience:
I am in a similar boat and trying to learn from others' experiences before my next appointment.
OP here — wow, did not expect this much response! Thank you all for the thoughtful replies on GLP-1 and addiction.
To answer zoe_NC: yes, I am on compounded sema from a 503B pharmacy.
Quick update: things are still going well. Thanks again for the evidence-based discussion — this is exactly why I posted in a science-based community. 🙏
Relevant to GLP-1 and addiction pathways — here is my latest bloodwork comparison:
Key improvements: A1C 8.4% → 5.5%, triglycerides 197 → 97 mg/dL, hsCRP 8.0 → 0.9 mg/L. All on tirzepatide for 13 months.
The inflammatory marker drop is what impresses me most. Consistent with the SELECT trial's cardiovascular findings.