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ForumsCardiovascular OutcomesNNT for MACE prevention — 6 month update Page 2

NNT for MACE prevention — 6 month update

MikeNYC_runner Mon, Aug 25, 2025 at 1:57 AM 12 replies 1,433 viewsPage 2 of 3
nick_SD_fit
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San Diego, CA
Aug 25, 2025 at 4:47 AM#6

Congrats MikeNYC_runner!! Keep going — you're doing incredible. 🎉

Last edited: Aug 25, 2025 at 6:47 AM
36 18SkepticalSean, Dr.CardioMD, EndoResFellow and 33 others
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Dr.PeteFamMed
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Minneapolis, MN
Aug 25, 2025 at 5:04 AM#7

Clinical perspective on NNT for MACE prevention 6 month update:

I have managed ~150 patients on GLP-1 therapy and this topic comes up frequently. What the data shows — and what I see in practice — is that proper titration prevents most adverse events.

For this specific question, I would recommend: reviewing the relevant clinical guidelines.

17 0tommy_boulder, hyun_seoul, jim_asheville and 14 others
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LibrarianMeg
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Aug 25, 2025 at 5:21 AM#8

100%. My provider said the same thing about NNT for MACE.

3 21julia.endo, JessicaM_2024, TomFromTexas
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RegAffairsDC
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May 2024
Washington, DC
Aug 25, 2025 at 5:38 AM#9

Reading this thread on NNT for MACE prevention hits close to home. Dad of 2 checking in — I started at 285 lbs and felt like I would tried everything.

11 months on tirz and I am a different person. Not just the 60 lbs lost — my energy, my mood, my relationship with food. All transformed.

If you are on the fence about NNT for MACE — take the leap. It was the best health decision I have ever made. ❤️

14 19sean_dublin, hannah_MT, Dr.SportsMedIN and 11 others
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Dr.NutriCornell
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Mar 2024
Ithaca, NY
Aug 25, 2025 at 5:55 AM#10
nick_SD_fit said:
Keep going — you're doing incredible

This is exactly right. nick_SD_fit articulated what I have been trying to explain to my doctor for months. The NNT for MACE prevention aspect is the most important factor.

9 15pat_auckland, Dr.GastroMayo, JakeBK_lifts and 6 others
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