Aug 25, 2025 at 6:12 AM#11
LibrarianMeg — wow. This community is amazing.
29 14TrialNerd_Beth, HPLC_Greg, LibrarianMeg and 26 others
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Aug 25, 2025 at 6:29 AM#12
Slightly tangential to NNT for MACE prevention but MikeNYC_runner reminded me — what is the latest on the oral formulations?
I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.
20 7Dr.PathRoch, mona_PHX, andrew_nyc and 17 others
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Aug 25, 2025 at 6:46 AM#13
Thanks for sharing this, MikeNYC_runner. A few questions about your NNT for MACE experience:
- What dose are you currently on?
- How long before you noticed significant changes?
- Did your doctor have any specific recommendations about NNT for MACE?
I am in a similar boat and trying to learn from others' experiences before my next appointment.
6 7LabKate, kate.chem, DataDave and 3 others
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Aug 25, 2025 at 7:03 AM#14
OP here — wow, did not expect this much response! Thank you all for the thoughtful replies on NNT for MACE prevention .
To answer jason_paloalto: yes, I am on compounded sema from a 503B pharmacy.
Quick update: things are still going well. Thanks again for the evidence-based discussion — this is exactly why I posted in a science-based community. 🙏
Last edited: Aug 25, 2025 at 9:03 AM
45 1GenomicsKate, Dr.ObesityMed, HealthEcon_DC and 42 others
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Aug 25, 2025 at 7:20 AM#15
Relevant to NNT for MACE prevention 6 — here is my latest bloodwork comparison:
Key improvements: A1C 7.6% → 5.5%, triglycerides 201 → 101 mg/dL, hsCRP 8.0 → 1.3 mg/L. All on tirzepatide for 17 months.
The inflammatory marker drop is what impresses me most. Consistent with the SELECT trial's cardiovascular findings.
Last edited: Aug 25, 2025 at 9:20 AM
50 8pete_manc_UK, anna.melb_AU, mark_tokyo and 47 others
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