Reading this thread on Heart rate increase on hits close to home. Night shift nurse — I started at 299 lbs and felt like I would tried everything.
15 months on tirz and I am a different person. Not just the 74 lbs lost — my energy, my mood, my relationship with food. All transformed.
If you are on the fence about Heart rate increase — take the leap. It was the best health decision I have ever made. ❤️
As a pharmacist, I want to add some clinical context to this discussion on Heart rate increase on GLP-1 November.
Building on what zoe_NC said — the evidence base here is robust. The key publications to reference are from the STEP program[1].
Key clinical points:
- Efficacy is dose-dependent and typically requires 4-5 weeks to reach steady state
- Side effect profile is predictable and usually manageable with standard protocols
- Monitoring should include baseline labs and follow-up at 3-month intervals
- Patient education significantly improves outcomes and adherence
Standard disclaimer: this is educational, not individualized medical advice.
[1] See thread title for relevant study identification.
Adding my data to this Heart rate increase on discussion:
| Metric | Baseline | Month 5 | Month 6 |
|---|---|---|---|
| Weight | 252 lbs | 222 lbs | 197 lbs |
| A1C | 6.6% | 6.0% | 5.2% |
| hsCRP | 6.0 | 4.0 | 1.0 |
Protocol: Semaglutide 1.7mg/wk, resistance training 3x/wk, protein 1.4g/kg/day.