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Forumsβ€ΊMASH / Liver Diseaseβ€ΊHas anyone dealt with de novo lipogenesis reduction on glp-1? β€Ί Page 3

Has anyone dealt with de novo lipogenesis reduction on glp-1?

NurseLeah_Nash Tue, Nov 18, 2025 at 1:33 AM 34 replies 1,698 viewsPage 3 of 7
WendyG_ATL
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Apr 2024
Georgia
Nov 18, 2025 at 5:48 AM#11

+1 to InsuranceTom. Especially the point about "NateNeph perspective but I think this ov..." β€” I have seen the same in my own experience with Has anyone dealt with de.

47 13Dr.SurgeonPGH, rachel_ABQ, traveltech_sara and 44 others
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PharmacoVig_BOS
Senior Member
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Feb 2024
Boston, MA
Nov 18, 2025 at 6:05 AM#12

Want to share my personal experience related to Has anyone dealt with de novo since I think it might help others in a similar situation.

I started my GLP-1 journey in October 2024 at 270 lbs with prediabetes and hypertension. My endocrinologist prescribed semaglutide 0.25mg to start.

Now, 8 months later: I am down 85 lbs, my labs have normalized, and I am off 2 of my 3 medications. The Has anyone dealt aspect specifically was something that made a big difference in my journey.

This community helped me every step of the way.

44 14Dr.GutHealth, amsterdam_pete, LondonLisa and 41 others
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mike_mealprep
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Chicago, IL
Nov 18, 2025 at 6:22 AM#13

hyun_seoul β€” that is really helpful context on Has anyone dealt with de. Follow-up question: did you experience any side effects during this phase?

I am in a similar situation (about to start) and trying to set realistic expectations.

11 3Dr.AddMedPHL, newstart_MO, mia_MS2 and 8 others
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Dr.RheumBOS
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Apr 2024
Boston, MA
Nov 18, 2025 at 6:39 AM#14

To answer PharmacoVig_BOS's question specifically:

From a clinical standpoint, Has anyone dealt with de novo is something I discuss with patients regularly.

The short answer: discuss this specific situation with your prescribing provider.

The longer answer involves weighing the risk-benefit ratio for your individual situation, which I am happy to elaborate on if helpful.

33 6lori_vegas, Dr.PulmRoch, maya_sedona and 30 others
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DebRD_ATL
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Nov 18, 2025 at 6:56 AM#15

Saving this for reference. Quality thread.

10 24HealthEcon_DC, PedsEndoPhilly, SleepDoc_PDX and 7 others
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