Moderator note: Reminder: nothing posted here constitutes medical advice. Consult your healthcare provider.
Tagging this for the weekly digest. 👍
Clinical perspective on Why does it stop working after a while:
I have managed roughly 300 patients on GLP-1 therapy and this topic comes up frequently. What the data shows — and what I see in practice — is that the medication works best as part of a comprehensive approach.
For this specific question, I would recommend: getting comprehensive baseline labs first.
Admin said:Consult your healthcare provider
I respect Admin perspective but I think this oversimplifies things a bit. Re: Why does it stop working after — the subgroup analyses show meaningful heterogeneity.
I am not saying Admin wrong entirely — just that the picture is more nuanced than a blanket statement. The STEP data specifically shows dose-dependent variation.
Reading this thread on Why does it stop working hits close to home. Night shift nurse — I started at 283 lbs and felt like I would tried everything.
9 months on tirz and I am a different person. Not just the 58 lbs lost — my energy, my mood, my relationship with food. All transformed.
If you are on the fence about Why does it stop — take the leap. It was the best health decision I have ever made. ❤️